MS 11, also known as the Syracuse Gradual is an extremely large (62 x 44 cm) and well-used Dominican Gradual of Saints, probably originating in Castile, Spain, and can be dated to the period of 1484--ca.1524. The text is in Latin with numerous marginal annotations in Spanish.

The book consists of the Sanctoral, or Proper of the Saints, used to celebrate the feast days of saints. Together with the Temporal (used to observe Sundays and holidays celebrating Christ), it was the main service book with musical notation made for medieval priests. All medieval churches and monasteries owned a gradual. They were made large so that the entire choir could sing from them. Due to their size and difficulties associated with printing music sheets, graduals were continued to be produced in manuscript for centuries after the advent of printing.

The liturgy combines elements from the Mozarabic rite, Roman/Gregorian use, and the Dominican tradition. The chant represents a transitional stage between the original Gregorian tradition and the revisions of Humbert de Romans.

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